Anti-aging Mass Building Supplements Human Menopausal Gonadotropin
HMG Menotropins Injection
Human Menopausal Gonadotropin,HMG, Menotropins for
Human Menopausal Gonadotropins are protein hormones secreted by
gonadotrope cells of the pituitary gland of vertebrates.
Gonadotropin is sometimes abbreviated Gn. The British spelling
The two principal gonadotropins are luteinizing hormone (LH) and
follicle stimulating hormone (FSH). Both hormones consist of two
peptide chains, an alpha chain and a beta chain, linked by Hydrogen
bonds and van der Waals forces. LH and FSH share nearly identical
alpha chains, while the beta chain provides specificity for
A third human gonadotropin is human chorionic gonadotropin (hCG),
produced by the placenta during pregnancy.
Gonadotropin receptors are embedded in the surface of the target
cell membranes and coupled to the G-protein system. Signals
triggered by binding to the receptor are relayed within the cells
by the cyclic AMP second messenger system.
Gonadotropins are released under the control of
gonadotropin-releasing hormone (GnRH) from the arcuate nucleus and
preoptic area of the hypothalamus. The gonads — testes and ovaries
— are the primary target organs for LH and FSH. The gonadotropins
affect multiple cell types and elicit multiple responses from the
target organs. As a simplified generalization, LH stimulates the
Leydig cells of the testes and the theca cells of the ovaries to
produce testosterone (and indirectly estradiol), while FSH
stimulates the spermatogenic tissue of the testes and the granulosa
cells of ovarian follicles.
Gonadotropin deficiency due to pituitary disease results in
hypogonadism, which can lead to infertility. Treatment include
administered gonadotropins, which therefore work as fertility
medication. Such can either be produced by extraction and
purification from urine or it can be produced by recombinant DNA.
Failure or loss of the gonads usually results in elevated levels of
LH and FSH in the blood.
MANNY RAMIREZ CONTROVERSY
Major League Baseball player Manny Ramirez was suspended for 50
games on May 6, 2009, for allegedly failing a drug test which
hMG is produced from a sterile preparation of placental
glucoprotein urine of post-menopausal women. The hMG is purified by
proprietary chromatographic techniques.
Physical Appearance: Sterile Filtered White lyophilized
Lyophilized from a concentrated (1 mg/ml) solution in water
containing no additives.
It is recommended to reconstitute the lyophilized hMG in sterile
18MO-cm H2O not less than 100 g/ml, which can then be further
diluted to other aqueous solutions.
Lyophilized hMG although stable at room temperature for 3 weeks,
should be stored desiccated below -18 C. Upon reconstitution hMG
should be stored at 4 C between 2-7 days and for future use below
-18 C. For long term storage it is recommended to add a carrier
protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.
Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b)
Anion-exchange FPLC. (c) Analysis by reducing and non-reducing
SDS-PAGE Silver Stained gel.
ProSpec's hMG conforms the following activities: 100IU/mg of FSH
and 100IU/mg LH.
Free of: HbsAg, Hepatitis B surface antigen and antibodies to HIV,
Hepatitis C and HCV.
Protein quantitation was carried out by two independent methods: 1.
UV spectroscopy at 280 nm . 2. Analysis by RP-HPLC, using a
standard solution of hMG as a Reference Standard.
should be stored desiccated below -18°C. Upon reconstitution HMG
should be stored at 4°C between 2-7 days and for future use below
-18°C. For long term storage it is recommended to add a carrier
protein (0.1% HSA or BSA). Please avoid freeze-thaw cycle.
Delivery and shipping:
1. We will ship the goods within 1 days after payment.
2.We will ship the goods by UPS,EMS,DHL, TNT or FEDEX . We will
choose the best courier depend on Different countries, and find the
safe way to deliver the goods for you.
3. Like Russia, Australia, Canada, customs is very strict, but we
can ensure 100% delivery.
4. As usual you can get the goods with in 4-7days. If the goods were
lost or not received for other reasons, we'll resend.
We have many regular customers worldwide, and hope to establish
long-term cooperation with you, For further informations please
feel free to contact us, we’ll do our best to fulfill your request.